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To kick in When snorted, cocaine can take from around 5 to 30 minutes to kick in, whereas the effects of smoking crack are almost instant. You might still experience some physical effects after the high has gone, such as a faster heart beat. The effects of smoking crack are even shorter lasting, around 10 minutes, with the peak lasting for about two minutes after smoking it. After effects Some people find that cocaine makes them feel down, anxious and paranoid the next day, or longer.